Risk-Adjusted Cancer Screening and Prevention (RiskAP): Integrating Prediction and Generation of Evidence in Digital Medicine

Final Meeting of the RiskAP Expert Group

In recent years, numerous risk factors for solid tumors have been identified. The focus here is on genetic changes that are hereditary and, according to current projections, are responsible for around one third of breast and colorectal cancer. These can be tested using multigene tests, which are now readily available in many EU countries. However, the interpretation of genetic information on risk prediction and clinical prediction programs based on it have not yet been sufficiently scientifically evaluated. It is still unclear whether risk-adjusted preventive measures actually reduce the mortality rate and to what extent they have a positive effect on the quality of life of those affected.
This discrepancy between the diagnostic offer and the evidence of clinical measures based on it requires new concepts. Since 2015, the international expert group on risk-adjusted prevention RiskAP has therefore been dealing intensely with the medical, ethical and legal challenges of genetic testing. The interdisciplinary project, funded by the German Federal Ministry of Health (BMG), aims to develop a conceptual framework and set international standards that address the manifold challenges in the field of early detection and prevention of hereditary tumors using breast cancer as an example.
At the conference, the group will present its findings and recommendations to the public and engage in discussion. The conference will be held in English.


11.00 a.m.

Welcoming Remarks
Antonius Helou, Federal Ministry of Health

11.10 a.m.

Opening and Thematic Setup
Rita Schmutzler, Christiane Woopen, Björn Schmitz-Luhn


New Knowledge in Prediction and Prevention: State of the Art
Session Chair: Rita Schmutzler

11.20 a.m.

Predictive Genetics
Diana Eccles

11.30 a.m.

Non-Genetic Risk Factors
Karin Kast

11.40 a.m.

Prediction Based on Risk Factors
Peter Devilee

11.50 a.m.


12.00 a.m.       

Lunch Break


Integrating New Knowledge into the Health System:
The RiskAP Proposal for Knowledge-Generating
Risk-Based Preventive Care

Session Chair: Björn Schmitz-Luhn

1.00 p.m.    

Improving Screening and Prevention
Bettina Borisch

1.20 p.m.

The Concept of RiskAP
Rita Schmutzler

1.40 p.m.

Public Health and the European Perspective
Marc von den Bulcke

2.00 p.m.

Ethical Potentials and Challenges
Christiane Woopen


Prerequisites for the Improvement of Predictive Care
Session Chair: Christiane Woopen

2.20 p.m.

The Patient Perspective
BRCA-Netzwerk Bonn

2.40 p.m.

Legal and Social Aspects: Genetic Diagnostics, Privacy, and Health Care System Integration
Björn Schmitz-Luhn

3.00 p.m.

Risk Literacy: How to Inform about Risks and Empower Patients?
Marcus Feufel


Final Discussion
Session Chairs: Rita Schmutzler, Christiane Woopen, Björn Schmitz-Luhn

3.20 p.m.

Panel with all Speakers

4.00 p.m.

End of Meeting

Date: November 6th, 2019

Time: 11:00 am – 4:00 pm

Location: Kalkscheune Berlin, Johannisstr. 2, D-10117 Berlin, Germany


Marion Rütten, M.A.

ceres – Cologne Center for Ethics, Rights, Economics, and Social Sciences of Health
Universitätsstr. 91
D-50931 Cologne

+49 (0)221 - 470 89101
ceres-sekretariat [at] uni-koeln.de