Professor John Ioannidis, M.D., D.Sc. from Stanford University shared his insights regarding the generation of medical evidence and present his research leading to his comprehensive methodological critique, which has made him one of the most cited and influential scientists worldwide. Together with the participants of this exclusive workshop, he highlighted the problems and shortcomings of the traditional methods, discussed modern alternatives which present themselves in light of the new possibilities to generate and use vast amounts of data, and debated the chances and challenges of their integration and transformation into modern health care.